May 13, 2013

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2013026914
Title: Preparation of benzoimidazolylmethylpyrimidinediamine derivatives and analogs for use as serine/threonine PAK1 inhibitors
Inventor(s): Aliagas-Martin, Ignacio; Crawford, James; Lee, Wendy; Mathieu, Simon; Rudolph, Joachim
Patent Assignee(s): F. Hoffmann-La Roche AG, Switz.
Source: PCT Int. Appl., 190pp. CODEN: PIXXD2
Language: English

Abstract:
Title compds. I and II [Z = N or CR2; each R1 independently = H, alkyl, haloalkyl, or alkoxyalkyl; or together are CH2CH2, (CH2)3, (CH2)4, or (CH2)5; R2 = H, alkyl, alkoxy, or cycloalkyl; R3 = H, alkyl, halo, alkoxy, etc.; each R4 independently = OH, CN, alkyl, etc.; R5 = H, alkyl, CN, haloalkyl, etc.; R6 = H, halo, alkyl, CN, etc.; R7 = alkyl, haloalkyl, (un)substituted cycloalkyl, etc.; R10 = H, alkyl, cycloalkyl, piperidinyl, etc.; R11 = H, alkyl, or cycloalkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as serine/threonine PAK1 inhibitors. Thus, e.g., III was prepd. by a multistep procedure (prepn. given). Select I and II were evaluated in GST-PAK1-KD (kinase domain) biochem. assays (data given).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention. The title of the U.S. granted patent is Processes for making hydrazides.

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