May 13, 2013

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2013026914
Title: Preparation of benzoimidazolylmethylpyrimidinediamine derivatives and analogs for use as serine/threonine PAK1 inhibitors
Inventor(s): Aliagas-Martin, Ignacio; Crawford, James; Lee, Wendy; Mathieu, Simon; Rudolph, Joachim
Patent Assignee(s): F. Hoffmann-La Roche AG, Switz.
Source: PCT Int. Appl., 190pp. CODEN: PIXXD2
Language: English

Abstract:
Title compds. I and II [Z = N or CR2; each R1 independently = H, alkyl, haloalkyl, or alkoxyalkyl; or together are CH2CH2, (CH2)3, (CH2)4, or (CH2)5; R2 = H, alkyl, alkoxy, or cycloalkyl; R3 = H, alkyl, halo, alkoxy, etc.; each R4 independently = OH, CN, alkyl, etc.; R5 = H, alkyl, CN, haloalkyl, etc.; R6 = H, halo, alkyl, CN, etc.; R7 = alkyl, haloalkyl, (un)substituted cycloalkyl, etc.; R10 = H, alkyl, cycloalkyl, piperidinyl, etc.; R11 = H, alkyl, or cycloalkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as serine/threonine PAK1 inhibitors. Thus, e.g., III was prepd. by a multistep procedure (prepn. given). Select I and II were evaluated in GST-PAK1-KD (kinase domain) biochem. assays (data given).

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention. The title of the U.S. granted patent is Processes for making hydrazides.

 View the full-text here.

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