The following record is from the CAplusSM database
CAPLUS COPYRIGHT 2009 ACS
| PATENT NUMBER: |
US 7511147 |
| TITLE: |
Process for manufacturing of chiral lobeline |
| INVENTOR(S): |
Klingler, Franz-Dietrich; Sobotta, Rainer |
| PATENT ASSIGNEE(S): |
Boehringer Ingelheim Pharma Gmbh & Co. KG, Germany |
| SOURCE: |
U.S. Pat. Appl. Publ., 4 pp. CODEN: USXXCO |
| LANGUAGE: |
English |
ABSTRACT:
This invention relates to a shortened process for prepg. L-lobeline (I) by rhodium-catalyzed asym. hydrogenation on an industrial scale. Thus, L-lobeline was prepd. with 29-35% yield via enantioselective hydrogenation of meso-lobelanine hydrochloride (II) using catalytic soln. prepd. by refluxing dichlorobis(1,5-cyclooctadiene)rhodium(I) and (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphinomethyl)-N-methylaminoc arbonylpyrrolidine in MeOH. |
| View the full text patent from USPTO. |
Updated: 4/30/2009 8:56:37 AM
