May 7, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8143406
Title: Process for preparation of HI-6 dimethanesulfonate
Inventor(s): Eddolls, Jonathan; McCormack, Peter; Hodgson, Anne
Patent Assignee(s): Phoenix Chemicals Limited, UK
Source: PCT Int. Appl., 25 pp. CODEN: PIXXD2
Language: English


The invention pertains to a process for the preparation of 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium dimethanesulfonate (HI-6 dimethanesulfonate), a bis-pyridinium oxime antidote to certain organophosphate nerve agents.  For example, O-acetyloxime-2-pyridinecarboxaldehyde (preparation given) was reacted with oxybismethanol dimethanesulfonate in methylene chloride and acetonitrile to form an intermediate compound, which was reacted with isonicotinamide to afford an O-protected HI-6 product precursor.  The precursor obtained above was then de-protected with ethanol to give HI-6 dimethanesulfonate as a final product. Advantageously, the title process for HI-6 production avoids the use of highly toxic or carcinogenic reagents, and is a convenient industrial scale process in which product yield and purity are com. satisfactory.

Please note:  Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced the title and abstract using additional information found in the patent. The original title of the U.S. granted patent is Process for the manufacture of HI-6 dimethanesulfonate. For the CAplus record, this title was enhanced to read Process for preparation of HI-6 dimethanesulfonate.


View the full-text U.S. patent from USPTO.

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