April 28, 2014

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8637713
Title: Process for the preparation of optically active hydroxyalkylphenols via asymmetric transfer hydrogenation of aryl ketones using chiral metal catalysts
Inventor(s): Mathes, Christian; Foulkes, Michael; Kesselgruber, Martin
Patent Assignee(s): Novartis AG, Switz.
Source: PCT Int. Appl., 69pp. CODEN: PIXXD2
Language: English

Title compds. (I; n = 1-5; R1 = alkyl, alkenyl, alkynyl, organohalide, aryl, amino, amido) were prepd. via asym. transfer hydrogenation of aryl ketones (II; variables as above) using chiral metal catalysts.  Thus, 1-(3-hydroxyphenyl)ethanone, (1R,2R)-chloro-N-(4-toluenesulfonyl-1,2- diphenylethylenediamine)(p-cymene)ruthenium, Et3N, and HCO2H were heated together to give 90% (R)-3-(1-hydroxyethyl)phenol in 99.3% enantiomeric excess.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.


 View the full-text here.

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