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CAPLUS COPYRIGHT 2014 ACS
||Process for the preparation of optically active hydroxyalkylphenols via asymmetric transfer hydrogenation of aryl ketones using chiral metal catalysts
||Mathes, Christian; Foulkes, Michael; Kesselgruber, Martin
||Novartis AG, Switz.
||PCT Int. Appl., 69pp. CODEN: PIXXD2
Title compds. (I; n = 1-5; R1 = alkyl, alkenyl, alkynyl, organohalide, aryl, amino, amido) were prepd. via asym. transfer hydrogenation of aryl ketones (II; variables as above) using chiral metal catalysts. Thus, 1-(3-hydroxyphenyl)ethanone, (1R,2R)-chloro-N-(4-toluenesulfonyl-1,2- diphenylethylenediamine)(p-cymene)ruthenium, Et3N, and HCO2H were heated together to give 90% (R)-3-(1-hydroxyethyl)phenol in 99.3% enantiomeric excess.
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