April 28, 2014

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2014 ACS

Patent Number: US 8637713
Title: Process for the preparation of optically active hydroxyalkylphenols via asymmetric transfer hydrogenation of aryl ketones using chiral metal catalysts
Inventor(s): Mathes, Christian; Foulkes, Michael; Kesselgruber, Martin
Patent Assignee(s): Novartis AG, Switz.
Source: PCT Int. Appl., 69pp. CODEN: PIXXD2
Language: English

Abstract:
Title compds. (I; n = 1-5; R1 = alkyl, alkenyl, alkynyl, organohalide, aryl, amino, amido) were prepd. via asym. transfer hydrogenation of aryl ketones (II; variables as above) using chiral metal catalysts.  Thus, 1-(3-hydroxyphenyl)ethanone, (1R,2R)-chloro-N-(4-toluenesulfonyl-1,2- diphenylethylenediamine)(p-cymene)ruthenium, Et3N, and HCO2H were heated together to give 90% (R)-3-(1-hydroxyethyl)phenol in 99.3% enantiomeric excess.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 

 View the full-text here.

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