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CAPLUS COPYRIGHT 2011 ACS
||Preparation of arylaminopropanols via ruthenium mediated enantioselective reduction of beta-hydroxy esters
||Eckert, Markus; Dreisbach, Claus; Bosch, Boris; Stolle, Andreas
||Bayer Aktiengesellschaft, Germany; Saltigo GmbH
||Eur. Pat. Appl., 24 pp. CODEN: EPXXDW
Title compds. I [Ar = (un)substituted aryl; R1, R2 = H, alkyl, aryl, etc.] were prepared. For example, LAH reduction of amide II, e.g., prepared from 2-acetylthiophene in 3-steps, afforded aminopropanol III in 84% yield. Compds. I are claimed useful intermediates for the production of pharmaceuticals.
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