April 25, 2011

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 7893281
Title: Preparation of arylaminopropanols via ruthenium mediated enantioselective reduction of beta-hydroxy esters
Inventor(s): Eckert, Markus; Dreisbach, Claus; Bosch, Boris; Stolle, Andreas
Patent Assignee(s): Bayer Aktiengesellschaft, Germany; Saltigo GmbH
Source: Eur. Pat. Appl., 24 pp. CODEN: EPXXDW
Language: German
Abstract:
Title compds. I [Ar = (un)substituted aryl; R1, R2 = H, alkyl, aryl, etc.] were prepared. For example, LAH reduction of amide II, e.g., prepared from 2-acetylthiophene in 3-steps, afforded aminopropanol III in 84% yield. Compds. I are claimed useful intermediates for the production of pharmaceuticals.

View the full-text patent from USPTO.

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