April 22, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8362303
Title: Process for producing aromatic aldehyde compound by coupling of (halomethyl)benzene with alkyl aldehyde
Inventor(s): Lee, Yu-Chin; Chang, Hsien-Yu; Chen, Han-Hsu; Hou, Yu-Sen; Liao, Rong-Yi
Patent Assignee(s): UFC Corporation, Taiwan
Source: U.S. Pat. Appl. Publ., 7pp. CODEN: USXXCO
Language: English

A process for producing an aromatic aldehyde compound has steps of converting alkyl-substituted or non-substituted benzene into a compound of formula (I; R1 = H, Me, Et, iso-Pr, iso-Bu, or tert-butyl; X = halogen) by halomethylation, and allowing the compound of formula I and alkyl aldehyde to react in presence of phase transfer catalyst represented by formula of tetraalkylammonium halide (II; R4, R5, R6 = C1-6 alkyl) at a reaction temperature under alkaline condition to obtain the aromatic aldehyde compound. Thus, 2.3 g NaOH, 0.26 g (4-tert-butylbenzyl)trimethylammonium bromide (phase transfer catalyst, preparation given), 7.5 mL water, 4.2 mL toluene, 1 mL THF were mixed in a flask and then heated to 70-75 degree C. A mixture of 10 g 4-tert-butylbenzyl bromide and 3.55 g propanal was added into the flask dropwise within 2 h while the reaction mixture was vigorously stirred. The reaction mixture was stirred at 70-75 degree C for 3 h to give, after workup and vacuum distillation, 7.43 g lysmeral (III) (82.6% yield and 97.27% purity) as compared to 53.8% yield when tetrabutylammonium iodide was used as the catalyst.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention. The title of the U.S. granted patent is Process for producing aromatic aldehyde compound.

 View the full-text here.

Recent News

    August 21, 2016 | CAS announces SciFindern, a new
    research experience that elevates scientific discovery

    August 19, 2016 | CAS seeks to help undergraduate
    students think like researchers with Chemistry
    Class Advantage, an organic chemistry learning
    solution powered by SciFinder

    August 1, 2016 | CAS Strengthens its Commitment to
    Science and Innovation Selecting 26 Outstanding
    International Scientists to Participate in the 2016
    SciFinder Future Leaders Program

                                                                       More News >> 

 Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624                                       
 Email: cas-pr@cas.org