April 21, 2014

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2014 ACS

Patent Number: US 8637673
Title: Method for producing 2,2-difluoroethylamine derivatives by imine hydrogenation
Inventor(s): Lui, Norbert; Antons, Stefan
Patent Assignee(s): Bayer CropScience AG, Germany
Source: PCT Int. Appl., 23pp.; Chemical Indexing Equivalent to 153:431215 (EP) CODEN: PIXXD2
Language: German

Abstract:
The invention relates to a method for prepg. 2,2-difluoroethylamine derivs. of formula I [A = substituted pyridinyl, substituted pyridazinyl, thiazolyl, etc.; R1, R2 = H, C1-4 alkyl] by hydrogenation of imines of formula II. The process for prepg. compds. of formula I via hydrogenation of imine II is claimed. Example compd. III was prepd. by condensation of 3-aminomethyl-6-chloropyridine with 2,2-difluoroacetaldehyde; the resulting 1-(6-chloropyridin-3-yl)-N-[(1E)-2,2- difluoroethylidene]methanamine underwent hydrogenation to give compd. III.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

 

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