April 21, 2014

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8637673
Title: Method for producing 2,2-difluoroethylamine derivatives by imine hydrogenation
Inventor(s): Lui, Norbert; Antons, Stefan
Patent Assignee(s): Bayer CropScience AG, Germany
Source: PCT Int. Appl., 23pp.; Chemical Indexing Equivalent to 153:431215 (EP) CODEN: PIXXD2
Language: German

The invention relates to a method for prepg. 2,2-difluoroethylamine derivs. of formula I [A = substituted pyridinyl, substituted pyridazinyl, thiazolyl, etc.; R1, R2 = H, C1-4 alkyl] by hydrogenation of imines of formula II. The process for prepg. compds. of formula I via hydrogenation of imine II is claimed. Example compd. III was prepd. by condensation of 3-aminomethyl-6-chloropyridine with 2,2-difluoroacetaldehyde; the resulting 1-(6-chloropyridin-3-yl)-N-[(1E)-2,2- difluoroethylidene]methanamine underwent hydrogenation to give compd. III.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.


 View the full-text here.

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