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CAPLUS COPYRIGHT 2014 ACS
||Method for producing 2,2-difluoroethylamine derivatives by imine hydrogenation
||Lui, Norbert; Antons, Stefan
||Bayer CropScience AG, Germany
||PCT Int. Appl., 23pp.; Chemical Indexing Equivalent to 153:431215 (EP) CODEN: PIXXD2
The invention relates to a method for prepg. 2,2-difluoroethylamine derivs. of formula I [A = substituted pyridinyl, substituted pyridazinyl, thiazolyl, etc.; R1, R2 = H, C1-4 alkyl] by hydrogenation of imines of formula II. The process for prepg. compds. of formula I via hydrogenation of imine II is claimed. Example compd. III was prepd. by condensation of 3-aminomethyl-6-chloropyridine with 2,2-difluoroacetaldehyde; the resulting 1-(6-chloropyridin-3-yl)-N-[(1E)-2,2- difluoroethylidene]methanamine underwent hydrogenation to give compd. III.
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