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CAPLUS COPYRIGHT 2012 ACS
||Process for the preparation of compounds via hazardous intermediates in a series of microreactors.
||Reintjens, Rafael Wilhelmus Elisabeth Ghislain; Broxterman, Quirinus Bernardus; Kotthaus, Martina; Poechlauer, Peter
||DSM IP Assets B.V., Neth.
||PCT Int. Appl., 22 pp. CODEN: PIXXD2
A multistep process for the preparation of compds. via hazardous intermediates comprises (a) preparing in a microreactor a hazardous intermediate, (b) optionally performing one or more reaction steps on the hazardous intermediate in one or more addnl. microreactors, and (c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed. Thus, aqueous NaN3 and 3-phenylpropanol mesylate in NMP were added to a mini tube reactor at 111-113 degree to give 95% conversion to 3-phenylpropyl azide after 60 min. The product solution was diluted with addnl. NMP and added along with H2 to a capillary reactor having a fused silica wall coated with alumina and Pd crystallites at 26 degree to give 3-phenyl-1-propylamine with 100% selectivity and 48% conversion.
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