March 12, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 62 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8106242
Title: Process for the preparation of compounds via hazardous intermediates in a series of microreactors.
Inventor(s): Reintjens, Rafael Wilhelmus Elisabeth Ghislain; Broxterman, Quirinus Bernardus; Kotthaus, Martina; Poechlauer, Peter
Patent Assignee(s): DSM IP Assets B.V., Neth.
Source: PCT Int. Appl., 22 pp. CODEN: PIXXD2
Language: English

A multistep process for the preparation of compds. via hazardous intermediates comprises (a) preparing in a microreactor a hazardous intermediate, (b) optionally performing one or more reaction steps on the hazardous intermediate in one or more addnl. microreactors, and (c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.  Thus, aqueous NaN3 and 3-phenylpropanol mesylate in NMP were added to a mini tube reactor at 111-113 degree to give 95% conversion to 3-phenylpropyl azide after 60 min.  The product solution was diluted with addnl. NMP and added along with H2 to a capillary reactor having a fused silica wall coated with alumina and Pd crystallites at 26 degree to give 3-phenyl-1-propylamine with 100% selectivity and 48% conversion.

Please note:  Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. CAS enhanced the abstract using additional information found in the patent.


View the full-text U.S. patent from USPTO.

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