March 5, 2012

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The following patent record is from the CAplusSM database.


Patent Number: US 8106189
Title: Process for preparation of triazolobenzodiazepine derivatives via cyclization of precursor N-acetylhydrazinobenzodiazepine substrates
Inventor(s): Naik, Anil M.; Sawant, Shrikant D.; Kavishwar, Girish A.; Kavishwar, Smita G.
Patent Assignee(s): Centaur Chemicals Pvt Ltd, India
Source: U.S. Pat. Appl. Publ., 6pp. CODEN: USXXCO
Language: English

There is disclosed a method for producing (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol (I) which comprises a step for obtaining a compound (II) by enantioselective addition reaction of an aldehyde   of formula R1O(CH2)3CHO (R1 = hydroxy-protecting group) with an acetaldehyde derivative of formula R2OCH2CHO (R2 = hydroxy-protecting) in the presence of an optionally substituted cyclic secondary amine, and a step for obtaining the compound II by removing R1 and R2 from the compound II sequentially or at a time and then cyclizing the compound from which the R1 and R2 are removed.

Please note:  Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced both the abstract and title using additional information found in the patent. The title of the U.S. granted patent is Process for preparation of triazol-benzodiazepine derivatives.


View the full-text U.S. patent from USPTO.

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