March 3, 2014

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8592631
Title: Process for the preparation of 2-methoxymethyl-1,4-benzenediamine, derivatives thereof and the salts thereof
Inventor(s): Gardlik, John Michael; Garrett, Garry Steven; Murphy, Bryan Patrick; Janusz, John Michael; Wos, John August
Patent Assignee(s): The Procter & Gamble Company, USA
Source: PCT Int. Appl., 34pp. CODEN: PIXXD2
Language: English

This invention relates to a process for synthesizing 2-methoxymethyl-1,4-benzenediamine (I), its derivs. II [R1-R3 = (un)substituted (hetero)alkyl, aryl, heteroaryl; R4 = H, hydroxyalkyl, (un)substituted alkyl, etc.; R5 = H, (un)substituted (hetero)alkyl, (un)substituted (un)satd. alkyl systems; R6, R7 = H, OH, alkyl, etc.; n = 0-3] and the salts thereof, which comprises a reductive amination step. The preferred final product is 2-methoxymethyl-1,4-benzenediamine (I). Thus, methylating 2-hydroxymethylphenol in MeOH followed by nitrosation of the resulting 2-methoxymethylphenol, condensation of III with hydroxylamine, and redn. of IV in the presence of a catalyst afforded the final product I.  These compds. may be used as primary intermediates in compns. for dyeing keratin fibers.

Please note:  Abstracts and Titles for patent records in CAplus are routinely enhanced to better describe the claimed invention.

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