February 28, 2011

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 61 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 7875729
Title: Process for preparation of trans-asenapine employing stereoselective hydrogenation of a dibenzoxepine intermediate
Inventor(s): Zhu, Jie; Keltjens, Rolf; Firet, Judith Janneke
Patent Assignee(s): Synthon B.V., Neth.
Source: PCT Int. Appl., 29pp. CODEN: PIXXD
Language: English
Abstract:
Asenapine and related trans-isomer bicyclic compds. can be obtained by reducing a compound of Formula (C) to preferentially form a trans-isomer compound of Formula (D), followed by subsequent ring closure to form a   compound of Formula (B) such as asenapine.  A method for preparing asenapine (I), and related trans-isomer bicyclic compds., is disclosed.  The  stereoselectivity arises via the hydrogenation of a dibenzoxepine    dicarboxylate intermediate II (R1 and R2 independently = alkyl, alkynyl or aralkyl group).  The reduction product of II (R1 and R2 = Me) then undergoes heterocyclization with methylamine to provide the desired I.

 

View the full-text patent from USPTO.

Recent News

       
    February 9, 2015 | Major New STN Release Delivers
    Essential Biomedical and Patent Content to IP
    Professionals
    
    January 26, 2015
 | Annual MEDLINE Reload on STN
    Features Enhanced Clinical Trial Information and the
    2015 MeSH Thesaurus
    
    January 23, 2015
 | STN Launches New Pricing
    Option for Information Brokers: Search Service
    Value Pricing
                               
  
                                                                     More News >> 

 Media Contact

 Name: Rhonda Ross
 Phone: 614-447-3624                                       
 Email: cas-pr@cas.org