February 25, 2013

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 63 patent authorities around the world, and other reputable web sources.  

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2013 ACS

Patent Number: WO 2012173849
Title: Preparation of pyrazole derivatives for use as aldosterone synthase inhibitors 
Inventor(s): Bell, Michael Gregory; Hoogestraat, Paul J.; Mabry, Thomas Edward; Shen, Quanrong; Escribano, Ana Maria
Patent Assignee(s): Eli Lilly and Company, USA
Source: PCT Int. Appl., 82pp. CODEN: PIXXD2
Language: English

Abstract:

Title compds. I [R1 and R2 independently = H, CH3, or CH2CH3; R3 = H, CN, F, Cl, Ch3, OCH3, or CF3; each R4 independently = F, Cl, Br, CH3, OCH3, CF3, or CN; X = CH2 or CH2CH2; n = 0 to 2], and their pharmaceutically acceptable salts, are prepared and disclosed as aldosterone synthase inhibitors. Thus, e.g., II was prepared by cyclization of 4-(3,3-dimethyl-4-oxocyclopentyl)benzonitrile with N,N-dimethylformamide di-Me acetal. Select I were evaluated in aldosterone synthase (hcyp11B2) inhibition assays, e.g., II demonstrated an IC50 value of 0.005 µM.

View the full-text patent here.

Note: Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced both the abstract and title using additional information found in the patent. The original title of the PCT patent publication is Pyrazole derivatives useful as aldosterone synthase inhibitors. For the CAplus record, this title was enhanced to read Preparation of pyrazole derivatives for use as aldosterone synthase inhibitors.

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