February 21, 2011

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The following patent record is from the CAplusSM database.


Patent Number: US 7858821
Title: A process for preparing intermediate compounds useful for producing dolasetron
Inventor(s): Perez Andres, Juan Antonio; Dalmases Barjoan, Pere; Huguet Clotet, Joan
Patent Assignee(s): Inke, S.A., Spain
Source: U.S. Pat. Appl. Publ., 20pp. CODEN: USXXCO
Language: English
The invention relates to a process for the preparation of compds. I (wherein R1 is alkyl, R2 and R3 are independently alkyl, or both R2 and R3 attached resp. to the oxygen atoms belonging to the same carbon atom form a cycle), which are useful for producing dolasetron.  For instance, the compound I (R1 = R2 = R3 = Me) was prepared by substitution of di-Me malonate with bromoacetaldehyde di-Me acetal followed by dealkoxycarbonylation in 75% yield, which was converted to dolasetron in about 5 steps.


View the full-text patent from USPTO.

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