February 20, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 62 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2012 ACS

Patent Number: US 8084630
Title: Process for the preparation of ramelteon and intermediates
Inventor(s): Kansal, Vinod Kumar; Mistry, Dhirenkumar N.; Vasoya, Sanjay L.; Rafilovich, Michal; Ben Moha-Lerman, Elena; Lifshitz-Liron, Revital
Patent Assignee(s): Teva Pharmaceutical Industries Ltd., Israel; Teva Pharmaceuticals USA, Inc.
Source: PCT Int. Appl., 81pp. CODEN: PIXXD2
Language: English

Abstract:
Non-electrostatic ramelteon was prepared starting from 2,3-dihydrobenzofuran and proceeding via acid (I).  I was resolved and (S)-I was amidated followed by reduction to the amine, acylation with propionyl chloride, and recrystn. from PhMe.

Please note:  Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. CAS enhanced the abstract using additional information found in the patent. Also, CAS indexed the PCT patent publication WO2008151170 as the first published record of the invention. The PCT publication lists both Teva Pharmaceutical Industries Ltd., Israel and Teva Pharmaceuticals USA, Inc., as the patent assignee. The patent assignee for the U.S. application and granted patent (US 8084630) is Teva Pharmaceutical Industries Ltd.

View the full-text U.S. patent from USPTO.

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