January 23, 2012

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 8067617
Title: Preparation of indolinonecarboxylates.
Inventor(s): Merten, Joern; Renner, Svenja; Reichel, Carsten
Patent Assignee(s): Boehringer Ingelheim International G.m.b.H., Germany
Source: PCT Int. Appl., 29pp. CODEN: PIXXD2
Language: English

Abstract:

Title compds. [I; R1 = H, ClCH2CO; R2, R3 = H; R2R3 = :C(OMe)Ph; when R1 = H, then R2R3 = :C(OMe)Ph], were prepared  Thus, di-Me malonate was heated with Na tert-amylate and Me 4-chloro-3-nitrobenzoate (preparation given) in N-methylpyrrolidone to give 95.4% di-Me [4-(methoxycarbonyl)-2-nitrophenyl]propanedioate. This was hydrogenated in HOAc over Pd/C at 45 degrees followed by heating at 115 degrees to give 87.2% 6-methoxycarbonyl-2-oxindole.

Please note:  Titles and abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced the abstract using additional information found in the patent.

View the full-text U.S. patent from USPTO.

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