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CAPLUS COPYRIGHT 2014 ACS
||Trka kinase inhibitors, compositions and methods thereof
||Stachel, Shawn J.; Egbertson, Melissa; Brnardic, Edward; Jones, Kristen; Sanders, John M.; Henze, Darrell A.
||Merck Sharp & Dohme Corp., USA
||PCT Int. Appl., 77pp. CODEN: PIXXD2
The present invention is directed to benzyl urea compds., which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder assocd. with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
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