January 9, 2012

CAS databases provide millions of journal article references from more than 10,000 major scientific journals worldwide, patent and patent family references from 62 patent authorities around the world, and other reputable web sources.

The following patent record is from the CAplusSM database.


Patent Number: US 8067594
Title: Process for the production of benzopyran-2-ol derivatives
Inventor(s): Ahman, Jens Bertil; Dillon, Barry Richard; Pettman, Alan John
Patent Assignee(s): Pfizer Limited, UK
Source: PCT Int. Appl., 37 pp. CODEN: PIXXD2
Language: English


The invention provides a process for the production of a compound of formula (I), wherein Y is selected from CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX is OH or O- M+, in which M+ is a cation selected from Li+, Na+ and K+, and Y is as defined above; with trans-cinnamaldehyde, in the presence of a secondary amine compound; then (ii) treating the product of the preceding step with acid to afford I.  Compds. I are intermediates useful in the production of tolterodine and fesoterodine, which are useful in the treatment of overactive bladder.

Please note:  Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced the abstract using additional information found in the patent.


View the full-text U.S. patent from USPTO.

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