January 2, 2012

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The following patent record is from the CAplusSM database.

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 8039678
Title: Process for the preparation of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
Inventor(s): Pacheco, Ogari; Teixeira, Antonio Carlos; Lima, Edson Luiz; Boeckelmann, Maria Alice
Patent Assignee(s): Cristalia Produtos Quimicos Farmaceuticos Ltda., Brazil
Source: PCT Int. Appl., 26 pp. CODEN: PIXXD2
Language: English

Abstract:
The present invention refers to a process for the preparation of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevochlorane) comprising reaction of hexafluoroisopropanol with a formaldehyde equivalent (paraformaldehyde or 1,3,5-trioxane) in the presence of a chlorinating agent and a strong acid. For example, hexafluoroisopropanol was reacted with paraformaldehyde at mole ratio of 1:1.5 in the presence of thionyl chloride and sulfuric acid to give sevochlorane (76.1%). Said process has advantages of high sevochlorane purity and yield.

Please note:  Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced the abstract using additional information found in the patent.

View the full-text U.S. patent from USPTO.


 

CAPLUS COPYRIGHT 2011 ACS

Patent Number: US 8044247
Title: Process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) from hexafluoroisopropanol and formaldehyde.
Inventor(s): Pacheco, Ogari; Teixeira, Antonio Carlos; Lima, Edson Luiz; Boeckelmann, Maria Alice
Patent Assignee(s): Cristalia Produtos Quimicos Farmaceuticos Ltda., Brazil
Source: PCT Int. Appl., 36pp. CODEN: PIXXD2
Language: English

Abstract:
A process for the preparation of sevoflurane comprises reaction of hexafluoroisopropanol with a formaldehyde equivalent (paraformaldehyde or 1,3,5-trioxane), a chlorinating agent selected from oxalyl chloride, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, sulfuryl chloride and thionyl chloride, and a strong acid selected from concentrated or fuming sulfuric acid to form sevochlorane which is converted to sevoflurane in a second step consisting of reacting sevochlorane with an alkali metal fluoride, or a linear or branched chain tetraalkyl quaternary ammonium fluoride in the presence of a substoichiometric quantity of an alkali metal iodide, or a linear or branched alkyl chain tetraalkyl quaternary ammonium iodide, preferably in a solvent.

Please note:  Abstracts for patent records in CAplus are routinely enhanced to better describe the claimed invention. In this example, CAS enhanced the abstract using additional information found in the patent.

View the full-text U.S. patent from USPTO.

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