On October 7, 2009, the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry to three scientists "for studies of the structure and function of the ribosome":
- Venkatraman Ramakrishnan, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
- Thomas A. Steitz, Yale University, New Haven, CT, USA
- Ada E. Yonath, Weizmann Institute of Science, Rehovot, Israel
Composed of RNA and protein, the ribosome is a large cellular molecule that serves as the catalytic machinery in the translation of RNA messages into functional protein. Using X-ray crystallography visualization techniques, Ramakrishnan, Steitz, and Yonath provided a high resolution map of the ribosome that led to significant advances in our understanding of just how these complex protein-building machines work.
Much of their Nobel Prize-winning research is represented in the CAS databases, with more than 200 references to their journal articles since 1980. Examples of their published research include:
- Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Wimberly, B. T.; Ramakrishnan, V. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 2000, 407 (6802), 340-348. SciFinder
- Schmeing, T. M.; Huang, K. S.; Kitchen, D. E.; Strobel, S. A.; Steitz, T. A. Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction. Mol. Cell 2005, 20 (3), 437-448. SciFinder
- Yonath, A. E.; Muessig, J.; Tesche, B.; Lorenz, S.; Erdmann, V. A.; Wittmann, H. G. Crystallization of the large ribosomal subunits from Bacillus stearothermophilus. Biochem. Int. J. 1980, 1 (5), 428-435. SciFinder
CAS congratulates the 2009 Nobel Laureates in Chemistry for their important contributions to science.
Peter S. Carlton, Ph.D.
You can use SciFinder® or STN® to search the CAS databases for additional information about the research of the 2009 Nobel Laureates in Chemistry. If your organization is enabled to use the web version of SciFinder, you can click the SciFinder links in this article to directly access details of the references.
For additional information, read the recent article in Chemical & Engineering News.
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