The Ten Most Frequently Cited Articles in the CAS Databases

The CAS cited reference collection has just exceeded 400 million! Here are the top ten most frequently cited articles (as of June 2014):

  1. Title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    Author: Bradford, Marion M.
    Organizational affiliation: Dep. Biochem., Univ. Georgia, Athens, GA, USA
    Source: Analytical Biochemistry (1976), 72(1-2), 248-54
    Number of times cited: 92,854


  2. Title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    Author: Laemmli, U. K.
    Organizational affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK
    Source: Nature (London, United Kingdom) (1970), 227(5259), 680- 685
    Number of times cited: 79,618


  3. Title: Protein measurement with the Folin phenol reagent
    Authors: Lowry, Oliver H.; Rosebrough, Nira J.; Farr, A. Lewis; Randall, Rose J.
    Organizational affiliation: Washington Univ., St. Louis, MO
    Source: Journal of Biological Chemistry (1951), 193, 265-75
    Number of times cited: 60,918


  4. Title: Density-functional thermochemistry. III. The role of exact exchange
    Author: Becke, Axel D.
    Organizational affiliation: Dep. Chem., Queen's Univ., Kingston, ON, K7L 3N6, Can.
    Source: Journal of Chemical Physics (1993), 98(7), 5648-52
    Number of times cited: 49,294


  5. Title: Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density
    Authors: Lee, Chengteh; Yang, Weitao; Parr, Robert G.
    Organizational affiliation: Dep. Chem., Univ. North Carolina, Chapel Hill, NC, 27514, USA
    Source: Physical Review B: Condensed Matter and Materials Physics (1988), 37(2), 785-9
    Number of times cited: 42,576


  6. Title: Generalized gradient approximation made simple
    Authors: Perdew, John P.; Burke, Kieron; Ernzerhof, Matthias
    Organizational affiliation: Dep. Phys. Quantum Theory Group, Tulane Univ., New Orleans, LA, 70118, USA
    Source: Physical Review Letters (1996), 77(18), 3865-3868
    Number of times cited: 37,052


  7. Title: Gapped BLAST and PSI-BLAST: a new generation of protein database search program
    Authors: Altschul, Stephen F.; Madden, Thomas L.;Schaffer, Alejandro A.; Zhang, Jinghui; Zhang, Zheng; Miller, Webb
    Organizational affiliation: Natl. Cent. Biotechnol. Information, Natl. Library Med., Natl. Inst. Health, Bethesda, MD, 20894, USA
    Source: Nucleic Acids Research (1997), 25(17), 3389-3402
    Number of times cited: 35,774


  8. Title: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    Authors: Thompson, Julie D.; Higgins, Desmond G.; Gibson, Toby J.
    Organizational affiliation: European Molecular Biology laboratory, Heidelberg, D-69012, Germany
    Source: Nucleic Acids Research (1994), 22(22), 4673-80
    Number of times cited: 33,197


  9. Title: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    Authors: Chomczynski, Piotr; Sacchi, Nicoletta
    Organizational affiliation: Lab. Biochem. Metabol., NIDDK, Bethesda, MD, 20892, USA
    Source: Analytical Biochemistry (1987), 162(1), 156-9
    Number of times cited: 32,340


  10. Title: Basic local alignment search tool
    Authors: Altschul, Stephen F.; Gish, Warren; Miller, Webb; Myers, Eugene W.; Lipman, David J.
    Organizational affiliation: Natl. Cent. Biotechnol. Inf., Natl. Library Med., Bethesda, MD, 20894, USA
    Source: Journal of Molecular Biology (1990), 215(3), 403-10
    Number of times cited: 29,977

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